Systemic epigenetic response to recombinant lentiviral vectors independent of proviral integration

BACKGROUND: Lentiviral vectors (LV) are widely used for various gene transfer or gene therapy applications. The effects of LV on target cells are expected to be limited to gene delivery. Yet, human hematopoietic CD34+ cells respond to functional LVs as well as several types of non-integrating LVs by...

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Detalhes bibliográficos
Publicado no:Epigenetics Chromatin
Main Authors: Aranyi, Tamas, Stockholm, Daniel, Yao, Roseline, Poinsignon, Catherine, Wiart, Thibaut, Corre, Guillaume, Touleimat, Nizar, Tost, Jörg, Galy, Anne, Paldi, Andràs
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4940770/
https://ncbi.nlm.nih.gov/pubmed/27408621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13072-016-0077-1
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