Galactosylated IgG1 links FcγRIIB and Dectin-1 to block complement-mediated inflammation

Complement is an ancient danger sensing system playing critical roles in host defense, immune surveillance and homeostasis(1). C5a and its G-Protein-coupled receptor mediate many of the pro-inflammatory properties of complement(2). Despite its critical role in allergic asthma(3), autoimmune arthriti...

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Autori principali: Karsten, Christian M., Pandey, Manoj K., Figge, Julia, Kilchenstein, Regina, Taylor, Philip R., Rosas, Marcela, McDonald, Jacqueline U., Orr, Selinda J., Berger, Markus, Petzold, Dominique, Blanchard, Veroniqué, Winkler, André, Hess, Constanze, Reid, Delyth M., Majoul, Irina V., Strait, Richard T., Harris, Nathaniel L., Köhl, Gabriele, Wex, Eva, Ludwig, Ralf, Zillikens, Detlef, Nimmerjahn, Falk, Finkelman, Fred D., Brown, Gordon D., Ehlers, Marc, Köhl, Jörg
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3492054/
https://ncbi.nlm.nih.gov/pubmed/22922409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2862
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