IgG-Independent Co-aggregation of FcεRI and FcγRIIB Results in LYN- and SHIP1-Dependent Tyrosine Phosphorylation of FcγRIIB in Murine Bone Marrow-Derived Mast Cells

Activation of the high-affinity receptor for IgE (FcεRI) follows a bell-shaped dose-response curve. Upon supra-optimal stimulation, mast cell effector responses are down-regulated by inhibitory molecules like the SH2-containing inositol-5′-phosphatase SHIP1 and the SRC-family-kinase LYN. To identify...

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Vydáno v:Front Immunol
Hlavní autoři: Gast, Mathias, Preisinger, Christian, Nimmerjahn, Falk, Huber, Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6119721/
https://ncbi.nlm.nih.gov/pubmed/30210494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01937
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