Prion Seeding Activities of Mouse Scrapie Strains with Divergent PrP(Sc) Protease Sensitivities and Amyloid Plaque Content Using RT-QuIC and eQuIC

Different transmissible spongiform encephalopathy (TSE)-associated forms of prion protein (e.g. PrP(Sc)) can vary markedly in ultrastructure and biochemical characteristics, but each is propagated in the host. PrP(Sc) propagation involves conversion from its normal isoform, PrP(C), by a seeded or te...

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Détails bibliographiques
Auteurs principaux: Vascellari, Sarah, Orrù, Christina D., Hughson, Andrew G., King, Declan, Barron, Rona, Wilham, Jason M., Baron, Gerald S., Race, Brent, Pani, Alessandra, Caughey, Byron
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2012
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3489776/
https://ncbi.nlm.nih.gov/pubmed/23139828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048969
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