Prion Seeding Activities of Mouse Scrapie Strains with Divergent PrP(Sc) Protease Sensitivities and Amyloid Plaque Content Using RT-QuIC and eQuIC

Different transmissible spongiform encephalopathy (TSE)-associated forms of prion protein (e.g. PrP(Sc)) can vary markedly in ultrastructure and biochemical characteristics, but each is propagated in the host. PrP(Sc) propagation involves conversion from its normal isoform, PrP(C), by a seeded or te...

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Detalhes bibliográficos
Main Authors: Vascellari, Sarah, Orrù, Christina D., Hughson, Andrew G., King, Declan, Barron, Rona, Wilham, Jason M., Baron, Gerald S., Race, Brent, Pani, Alessandra, Caughey, Byron
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3489776/
https://ncbi.nlm.nih.gov/pubmed/23139828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048969
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