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Normalization and missing value imputation for label-free LC-MS analysis

Shotgun proteomic data are affected by a variety of known and unknown systematic biases as well as high proportions of missing values. Typically, normalization is performed in an attempt to remove systematic biases from the data before statistical inference, sometimes followed by missing value imput...

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Autori principali: Karpievitch, Yuliya V, Dabney, Alan R, Smith, Richard D
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3489534/
https://ncbi.nlm.nih.gov/pubmed/23176322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-13-S16-S5
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