Normalization of peak intensities in bottom-up MS-based proteomics using singular value decomposition

Motivation: LC-MS allows for the identification and quantification of proteins from biological samples. As with any high-throughput technology, systematic biases are often observed in LC-MS data, making normalization an important preprocessing step. Normalization models need to be flexible enough to...

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Hlavní autoři: Karpievitch, Yuliya V., Taverner, Thomas, Adkins, Joshua N., Callister, Stephen J., Anderson, Gordon A., Smith, Richard D., Dabney, Alan R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2009
Témata:
Original Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2752608/
https://ncbi.nlm.nih.gov/pubmed/19602524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btp426
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