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Normalization and missing value imputation for label-free LC-MS analysis

Shotgun proteomic data are affected by a variety of known and unknown systematic biases as well as high proportions of missing values. Typically, normalization is performed in an attempt to remove systematic biases from the data before statistical inference, sometimes followed by missing value imput...

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Detalhes bibliográficos
Main Authors: Karpievitch, Yuliya V, Dabney, Alan R, Smith, Richard D
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3489534/
https://ncbi.nlm.nih.gov/pubmed/23176322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-13-S16-S5
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