Ligand-binding domain of an α(7)-nicotinic receptor chimera and its complex with agonist

The α(7) acetylcholine receptor (AChR) mediates pre- and postsynaptic neurotransmission in the central nervous system and is a potential therapeutic target in neurodegenerative, neuropsychiatric and inflammatory disorders. We determined the crystal structure of the extracellular domain of a receptor...

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Bibliographic Details
Main Authors: Li, Shu-Xing, Huang, Sun, Bren, Nina, Noridomi, Kaori, Dellisanti, Cosma D, Sine, Steven M, Chen, Lin
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3489043/
https://ncbi.nlm.nih.gov/pubmed/21909087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2908
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