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Ligand-binding domain of an α(7)-nicotinic receptor chimera and its complex with agonist
The α(7) acetylcholine receptor (AChR) mediates pre- and postsynaptic neurotransmission in the central nervous system and is a potential therapeutic target in neurodegenerative, neuropsychiatric and inflammatory disorders. We determined the crystal structure of the extracellular domain of a receptor...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3489043/ https://ncbi.nlm.nih.gov/pubmed/21909087 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2908 |
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