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Role of Key Aromatic Residues in the Ligand-binding Domain of α7 Nicotinic Receptors in the Agonist Action of β-Amyloid

Soluble β-amyloid (Aβ) resides in certain regions of the brain at or near picomolar concentration, rising in level during the prodromic stage of Alzheimer disease. Recently, we identified the homomeric α7 nicotinic acetylcholine receptor (α7-nAChR) as one possible functional target for picomolar Aβ....

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Detalhes bibliográficos
Main Authors: Tong, Mei, Arora, Komal, White, Michael M., Nichols, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190827/
https://ncbi.nlm.nih.gov/pubmed/21828053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.241299
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