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Determination of the Residues in the Extracellular Domain of the Nicotinic α Subunit Required for the Actions of Physostigmine on Neuronal Nicotinic Receptors

Physostigmine can potentiate and inhibit neuronal nicotinic receptors, in addition to inhibiting the activity of acetylcholinesterase. We found that receptors containing three copies of the α2 subunit are inhibited by low concentrations of physostigmine in contrast to receptors containing three copi...

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Pubblicato in:Mol Pharmacol
Autori principali: Jin, Xiaochun, Germann, Allison L., Shin, Daniel J., Akk, Gustav, Steinbach, Joe Henry
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5548365/
https://ncbi.nlm.nih.gov/pubmed/28630263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.117.108894
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