Glutaraldehyde-Modified Recombinant Fel d 1: A Hypoallergen With Negligible Biological Activity But Retained Immunogenicity

BACKGROUND: Recombinant allergens are under investigation for replacing allergen extracts in immunotherapy. Site-directed mutagenesis has been suggested as a strategy to develop hypoallergenic molecules that will reduce the risk of side effects. For decades, chemically modified allergen extracts hav...

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Main Authors: Versteeg, Serge A., Bulder, Ingrid, Himly, Martin, van Capel, Toni M., van den Hout, R., Koppelman, Stef J., de Jong, Esther C., Ferreira, Fatima, van Ree, Ronald
格式: Artigo
語言:Inglês
出版: World Allergy Organization Journal 2011
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Original Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488918/
https://ncbi.nlm.nih.gov/pubmed/23268458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/WOX.0b013e3182228a39
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