Rational Design, Structure–Activity Relationship, and Immunogenicity of Hypoallergenic Pru p 3 Variants

SCOPE: Allergies to lipid transfer proteins involve severe adverse reactions; thus, effective and sustainable therapies are desired. Previous attempts disrupting disulfide bonds failed to maintain immunogenicity; thus, the aim is to design novel hypoallergenic Pru p 3 variants and evaluate the appli...

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Detalhes bibliográficos
Publicado no:Mol Nutr Food Res
Main Authors: Eichhorn, Stephanie, Hörschläger, Angelika, Steiner, Markus, Laimer, Josef, Jensen, Bettina M, Versteeg, Serge A, Pablos, Isabel, Briza, Peter, Jongejan, Laurian, Rigby, Neil, Asturias, Juan A, Portolés, Antonio, Fernandez‐Rivas, Montserrat, Papadopoulos, Nikolaos G, Mari, Adriano, Poulsen, Lars K, Lackner, Peter, van Ree, Ronald, Ferreira, Fatima, Gadermaier, Gabriele
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6790652/
https://ncbi.nlm.nih.gov/pubmed/31207117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mnfr.201900336
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