Rational Design, Structure–Activity Relationship, and Immunogenicity of Hypoallergenic Pru p 3 Variants

SCOPE: Allergies to lipid transfer proteins involve severe adverse reactions; thus, effective and sustainable therapies are desired. Previous attempts disrupting disulfide bonds failed to maintain immunogenicity; thus, the aim is to design novel hypoallergenic Pru p 3 variants and evaluate the appli...

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Publicado en:Mol Nutr Food Res
Autores principales: Eichhorn, Stephanie, Hörschläger, Angelika, Steiner, Markus, Laimer, Josef, Jensen, Bettina M, Versteeg, Serge A, Pablos, Isabel, Briza, Peter, Jongejan, Laurian, Rigby, Neil, Asturias, Juan A, Portolés, Antonio, Fernandez‐Rivas, Montserrat, Papadopoulos, Nikolaos G, Mari, Adriano, Poulsen, Lars K, Lackner, Peter, van Ree, Ronald, Ferreira, Fatima, Gadermaier, Gabriele
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6790652/
https://ncbi.nlm.nih.gov/pubmed/31207117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mnfr.201900336
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