Synthesis and SAR of Tetrahydroisoquinolines as Rev-erbα agonists

The design and synthesis of a novel series of Rev-erbα agonists is described. The development and optimization of the tetrahydroisoquinoline series was carried out from an earlier acyclic series of Rev-erbα agonists. Through the optimization of the scaffold 1, several potent compounds with good in v...

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Hlavní autoři: Noel, Romain, Song, Xinyi, Shin, Youseung, Banerjee, Subhashis, Kojetin, Douglas, Lin, Li, Ruiz, Claudia H., Cameron, Michael D., Burris, Thomas P., Kamenecka, Theodore M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488456/
https://ncbi.nlm.nih.gov/pubmed/22560469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.04.023
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