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Synthesis and SAR of Tetrahydroisoquinolines as Rev-erbα agonists
The design and synthesis of a novel series of Rev-erbα agonists is described. The development and optimization of the tetrahydroisoquinoline series was carried out from an earlier acyclic series of Rev-erbα agonists. Through the optimization of the scaffold 1, several potent compounds with good in v...
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| Autori principali: | , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3488456/ https://ncbi.nlm.nih.gov/pubmed/22560469 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.04.023 |
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