Small Molecule Tertiary Amines as Agonists of the Nuclear Hormone Receptor Rev-erbα

The structure activity relationship study of a small molecule Rev-erbα agonist is reported. The potency and efficacy of the agonists in a cell-based assay were optimized as compared to the initial lead. Modest mouse pharmacokinetics coupled with an improved in vitro profile make 12e a suitable in vi...

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Detalhes bibliográficos
Main Authors: Shin, Youseung, Noel, Romain, Banerjee, Subhashis, Kojetin, Douglas, Song, Xinyi, He, Yuanjun, Lin, Li, Cameron, Michael D., Burris, Thomas P., Kamenecka, Theodore M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3376186/
https://ncbi.nlm.nih.gov/pubmed/22633688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.04.126
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