En bloc transfer of polyubiquitin chains to PCNA in vitro is mediated by two different human E2–E3 pairs

Post-replication DNA repair in eukaryotes is regulated by ubiquitination of proliferating cell nuclear antigen (PCNA). Monoubiquitination catalyzed by RAD6–RAD18 (an E2–E3 complex) stimulates translesion DNA synthesis, whereas polyubiquitination, promoted by additional factors such as MMS2–UBC13 (a...

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Detalhes bibliográficos
Main Authors: Masuda, Yuji, Suzuki, Miki, Kawai, Hidehiko, Hishiki, Asami, Hashimoto, Hiroshi, Masutani, Chikahide, Hishida, Takashi, Suzuki, Fumio, Kamiya, Kenji
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Nucleic Acid Enzymes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488225/
https://ncbi.nlm.nih.gov/pubmed/22904075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks763
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