En bloc transfer of polyubiquitin chains to PCNA in vitro is mediated by two different human E2–E3 pairs

Post-replication DNA repair in eukaryotes is regulated by ubiquitination of proliferating cell nuclear antigen (PCNA). Monoubiquitination catalyzed by RAD6–RAD18 (an E2–E3 complex) stimulates translesion DNA synthesis, whereas polyubiquitination, promoted by additional factors such as MMS2–UBC13 (a...

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Bibliografische gegevens
Hoofdauteurs: Masuda, Yuji, Suzuki, Miki, Kawai, Hidehiko, Hishiki, Asami, Hashimoto, Hiroshi, Masutani, Chikahide, Hishida, Takashi, Suzuki, Fumio, Kamiya, Kenji
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2012
Onderwerpen:
Nucleic Acid Enzymes
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488225/
https://ncbi.nlm.nih.gov/pubmed/22904075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks763
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