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Regulation of PCNA polyubiquitination in human cells

BACKGROUND: The ubiquitin-based molecular switch dictating error free versus error prone repair has been conserved throughout eukaryotic evolution. A central component of this switch is the homotrimeric clamp PCNA, which is ubiquitinated in response to genotoxic stress allowing recovery of replicati...

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Detalhes bibliográficos
Main Authors: Brun, Jan, Chiu, Roland K, Wouters, Bradly G, Gray, Douglas A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867771/
https://ncbi.nlm.nih.gov/pubmed/20353596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-0500-3-85
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