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PCNA-Ub polyubiquitination inhibits cell proliferation and induces cell-cycle checkpoints
In response to replication-blocking lesions, proliferating cell nuclear antigen (PCNA) can be sequentially ubiquitinated at the K164 residue leading to 2 modes of DNA-damage tolerance, namely translesion DNA synthesis (TLS) and error-free lesion bypass. Ectopic expression of PCNA fused with ubiquiti...
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| Publicado no: | Cell Cycle |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5224464/ https://ncbi.nlm.nih.gov/pubmed/27753536 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2016.1245247 |
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