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The mouse polyubiquitin gene UbC is essential for fetal liver development, cell-cycle progression and stress tolerance
UbC is one of two stress-inducible polyubiquitin genes in mammals and is thought to supplement the constitutive UbA genes in maintaining cellular ubiquitin (Ub) levels during episodes of cellular stress. We have generated mice harboring a targeted disruption of the UbC gene. UbC(−/−) embryos die bet...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1888680/ https://ncbi.nlm.nih.gov/pubmed/17491588 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601722 |
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