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Hypothalamic neurodegeneration and adult-onset obesity in mice lacking the Ubb polyubiquitin gene
Nearly all neurodegenerative diseases are associated with abnormal accumulation of ubiquitin (Ub) conjugates within neuronal inclusion bodies. To directly test the hypothesis that depletion of cellular Ub is sufficient to cause neurodegeneration, we have disrupted Ubb, one of four genes that supply...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2268782/ https://ncbi.nlm.nih.gov/pubmed/18299572 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800096105 |
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