The leptin hypothesis of depression: a potential link between mood disorders and obesity?

Por Lu, Xin-Yun
Publicado em 2007

Dentate gyrus–CA3 glutamate release/NMDA transmission mediates behavioral despair and antidepressant-like responses to leptin

Por Wang, Xuezhen, Zhang, Di, Lu, Xin-Yun
Publicado no Mol Psychiatry (2014)

Leptin/LepRb in the Ventral Tegmental Area Mediates Anxiety-Related Behaviors

Por Liu, Jing, Guo, Ming, Lu, Xin-Yun
Publicado no Int J Neuropsychopharmacol (2015)

Adiponectin Exerts Neurotrophic Effects on Dendritic Arborization, Spinogenesis, and Neurogenesis of the Dentate Gyrus of Male Mice

Por Zhang, Di, Wang, Xuezhen, Lu, Xin-Yun
Publicado no Endocrinology (2016)

Adiponectin Stimulates Proliferation of Adult Hippocampal Neural Stem/Progenitor Cells through Activation of p38 Mitogen-activated Protein Kinase (p38MAPK)/Glycogen Synthase Kinase...

Por Zhang, Di, Guo, Ming, Zhang, Wei, Lu, Xin-Yun
Publicado em 2011

Sex-Specific and Estrous Cycle-Dependent Antidepressant-Like Effects and Hippocampal Akt Signaling of Leptin

Por Carrier, Nicole, Wang, Xuezhen, Sun, Linshan, Lu, Xin-Yun
Publicado no Endocrinology (2015)

Leptin: A potential novel antidepressant

Por Lu, Xin-Yun, Kim, Chung Sub, Frazer, Alan, Zhang, Wei
Publicado em 2006

Leptin Increases Adult Hippocampal Neurogenesis in Vivo and in Vitro

Por Garza, Jacob C., Guo, Ming, Zhang, Wei, Lu, Xin-Yun
Publicado em 2008

Leptin restores adult hippocampal neurogenesis suppressed by chronic unpredictable stress and reverses glucocorticoid-induced inhibition of GSK3β/β-catenin signaling

Por Garza, Jacob C., Guo, Ming, Zhang, Wei, Lu, Xin-Yun
Publicado em 2011

Melanocortin-4 receptor in the medial amygdala regulates emotional stress-induced anxiety-like behaviour, anorexia and corticosterone secretion

Por Liu, Jing, Garza, Jacob C., Li, Wei, Lu, Xin-Yun
Publicado em 2011

Selective Deletion of the Leptin Receptor in Dopamine Neurons Produces Anxiogenic-like Behavior and Increases Dopaminergic Activity in Amygdala

Por Liu, Jing, Perez, Stephanie M., Zhang, Wei, Lodge, Daniel J., Lu, Xin-Yun
Publicado em 2011

Adeno-associated virus-mediated knockdown of melanocortin-4 receptor in the paraventricular nucleus of the hypothalamus promotes high-fat diet-induced hyperphagia and obesity

Por Garza, Jacob C, Kim, Chung Sub, Liu, Jing, Zhang, Wei, Lu, Xin-Yun
Publicado em 2008

Hypothalamic neurodegeneration and adult-onset obesity in mice lacking the Ubb polyubiquitin gene

Por Ryu, Kwon-Yul, Garza, Jacob C., Lu, Xin-Yun, Barsh, Gregory S., Kopito, Ron R.
Publicado em 2008

Selective deletion of leptin receptors in adult hippocampus induces depression-related behaviors

Por Guo, Ming, Huang, Tung-Yi, Garza, Jacob C., Chua, Streamson C., Lu, Xin-Yun
Publicado em 2012

The Melanocortinergic Pathway Is Rapidly Recruited by Emotional Stress and Contributes to Stress-Induced Anorexia and Anxiety-Like Behavior

Por Liu, Jing, Garza, Jacob C., Truong, Ha V., Henschel, John, Zhang, Wei, Lu, Xin-Yun
Publicado em 2007

Acute administration of leptin produces anxiolytic-like effects: a comparison with fluoxetine

Por Liu, Jing, Garza, Jacob C., Bronner, Jamaur, Kim, Chung Sub, Zhang, Wei, Lu, Xin-Yun
Publicado em 2009

Cognitive and neural correlates of depression-like behaviour in socially defeated mice: an animal model of depression with cognitive dysfunction

Por Yu, Tao, Guo, Ming, Garza, Jacob, Rendon, Samantha, Sun, Xue-Li, Zhang, Wei, Lu, Xin-Yun
Publicado em 2010

Adiponectin is critical in determining susceptibility to depressive behaviors and has antidepressant-like activity

Por Liu, Jing, Guo, Ming, Zhang, Di, Cheng, Shao-Ying, Liu, Meilian, Ding, Jun, Scherer, Philipp E., Liu, Feng, Lu, Xin-Yun
Publicado em 2012

Glucocorticoid receptor overexpression in forebrain: A mouse model of increased emotional lability

Por Wei, Qiang, Lu, Xin-Yun, Liu, Li, Schafer, Gwen, Shieh, Kun-Ruey, Burke, Sharon, Robinson, Terry E., Watson, Stanley J., Seasholtz, Audrey F., Akil, Huda
Publicado em 2004

Disruption of Growth Factor Receptor–Binding Protein 10 in the Pancreas Enhances β-Cell Proliferation and Protects Mice From Streptozotocin-Induced β-Cell Apoptosis

Por Zhang, Jingjing, Zhang, Ning, Liu, Meilian, Li, Xiuling, Zhou, Lijun, Huang, Wei, Xu, Zhipeng, Liu, Jing, Musi, Nicolas, DeFronzo, Ralph A., Cunningham, John M., Zhou, Zhiguang, Lu, Xin-Yun, Liu, Feng
Publicado em 2012