The mouse polyubiquitin gene UbC is essential for fetal liver development, cell-cycle progression and stress tolerance

UbC is one of two stress-inducible polyubiquitin genes in mammals and is thought to supplement the constitutive UbA genes in maintaining cellular ubiquitin (Ub) levels during episodes of cellular stress. We have generated mice harboring a targeted disruption of the UbC gene. UbC(−/−) embryos die bet...

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Main Authors: Ryu, Kwon-Yul, Maehr, René, Gilchrist, Catherine A, Long, Michael A, Bouley, Donna M, Mueller, Britta, Ploegh, Hidde L, Kopito, Ron R
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2007
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1888680/
https://ncbi.nlm.nih.gov/pubmed/17491588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601722
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