Histone Deacetylase Inhibitor (HDACi) Suberoylanilide Hydroxamic Acid (SAHA)-mediated Correction of α1-Antitrypsin Deficiency

α1-Antitrypsin (α1AT) deficiency (α1ATD) is a consequence of defective folding, trafficking, and secretion of α1AT in response to a defect in its interaction with the endoplasmic reticulum proteostasis machineries. The most common and severe form of α1ATD is caused by the Z-variant and is characteri...

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Main Authors: Bouchecareilh, Marion, Hutt, Darren M., Szajner, Patricia, Flotte, Terence R., Balch, William E.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2012
主題:
Cell Biology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488095/
https://ncbi.nlm.nih.gov/pubmed/22995909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.404707
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