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A Sequential Mechanism for Exosite-mediated Factor IX Activation by Factor XIa
During blood coagulation, the protease factor XIa (fXIa) activates factor IX (fIX). We describe a new mechanism for this process. FIX is cleaved initially after Arg(145) to form fIXα, and then after Arg(180) to form the protease fIXaβ. FIXα is released from fXIa, and must rebind for cleavage after A...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3488089/ https://ncbi.nlm.nih.gov/pubmed/22961984 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.376343 |
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