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A Sequential Mechanism for Exosite-mediated Factor IX Activation by Factor XIa

During blood coagulation, the protease factor XIa (fXIa) activates factor IX (fIX). We describe a new mechanism for this process. FIX is cleaved initially after Arg(145) to form fIXα, and then after Arg(180) to form the protease fIXaβ. FIXα is released from fXIa, and must rebind for cleavage after A...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Geng, Yipeng, Verhamme, Ingrid M., Messer, Amanda, Sun, Mao-fu, Smith, Stephen B., Bajaj, S. Paul, Gailani, David
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2012
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488089/
https://ncbi.nlm.nih.gov/pubmed/22961984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.376343
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