A Sequential Mechanism for Exosite-mediated Factor IX Activation by Factor XIa

During blood coagulation, the protease factor XIa (fXIa) activates factor IX (fIX). We describe a new mechanism for this process. FIX is cleaved initially after Arg(145) to form fIXα, and then after Arg(180) to form the protease fIXaβ. FIXα is released from fXIa, and must rebind for cleavage after A...

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Bibliographic Details
Main Authors: Geng, Yipeng, Verhamme, Ingrid M., Messer, Amanda, Sun, Mao-fu, Smith, Stephen B., Bajaj, S. Paul, Gailani, David
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Enzymology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488089/
https://ncbi.nlm.nih.gov/pubmed/22961984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.376343
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