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A Single Native Ganglioside GM(1)-Binding Site Is Sufficient for Cholera Toxin To Bind to Cells and Complete the Intoxication Pathway

Cholera toxin (CT) from Vibrio cholerae is responsible for the majority of the symptoms of the diarrheal disease cholera. CT is a heterohexameric protein complex with a 240-residue A subunit and a pentameric B subunit of identical 103-residue B polypeptides. The A subunit is proteolytically cleaved...

詳細記述

保存先:
書誌詳細
主要な著者: Jobling, Michael G., Yang, ZhiJie, Kam, Wendy R., Lencer, Wayne I., Holmes, Randall K.
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Microbiology 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3487775/
https://ncbi.nlm.nih.gov/pubmed/23111873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00401-12
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