A Single Native Ganglioside GM(1)-Binding Site Is Sufficient for Cholera Toxin To Bind to Cells and Complete the Intoxication Pathway

Cholera toxin (CT) from Vibrio cholerae is responsible for the majority of the symptoms of the diarrheal disease cholera. CT is a heterohexameric protein complex with a 240-residue A subunit and a pentameric B subunit of identical 103-residue B polypeptides. The A subunit is proteolytically cleaved...

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Bibliografiska uppgifter
Huvudupphovsmän: Jobling, Michael G., Yang, ZhiJie, Kam, Wendy R., Lencer, Wayne I., Holmes, Randall K.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Microbiology 2012
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3487775/
https://ncbi.nlm.nih.gov/pubmed/23111873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00401-12
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