Attenuated Endocytosis and Toxicity of a Mutant Cholera Toxin with Decreased Ability To Cluster Ganglioside GM(1) Molecules

Cholera toxin (CT) moves from the plasma membrane (PM) of host cells to the endoplasmic reticulum (ER) by binding to the lipid raft ganglioside GM(1). The homopentomeric B-subunit of the toxin can bind up to five GM(1) molecules at once. Here, we examined the role of polyvalent binding of GM(1) in C...

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Hlavní autoři: Wolf, Anne A., Jobling, Michael G., Saslowsky, David E., Kern, Eli, Drake, Kimberly R., Kenworthy, Anne K., Holmes, Randall K., Lencer, Wayne I.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2008
Témata:
Molecular Pathogenesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292862/
https://ncbi.nlm.nih.gov/pubmed/18212085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01286-07
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