The sorafenib plus nutlin-3 combination promotes synergistic cytotoxicity in acute myeloid leukemic cells irrespectively of FLT3 and p53 status

BACKGROUND: Both the multi-kinase inhibitor sorafenib and the small molecule inhibitor of the MDM2/p53 interaction, nutlin-3, used alone, have shown promising anti-leukemic activity in acute myeloid leukemia cells. Thus, in this study we investigated the effect of the combination of sorafenib plus n...

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Autors principals: Zauli, Giorgio, Celeghini, Claudio, Melloni, Elisabetta, Voltan, Rebecca, Ongari, Manuele, Tiribelli, Mario, di Iasio, Maria Grazia, Lanza, Francesco, Secchiero, Paola
Format: Artigo
Idioma:Inglês
Publicat: Ferrata Storti Foundation 2012
Matèries:
Original Articles and Brief Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3487447/
https://ncbi.nlm.nih.gov/pubmed/22689683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2012.062083
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