Metformin combined with sodium dichloroacetate promotes B leukemic cell death by suppressing anti-apoptotic protein Mcl-1

Metformin and the mitochondrial targeting dichloroacetate (DCA) have recently received attention due to their ability to inhibit anaerobic glycolysis, which renders most cancer cells resistant to apoptosis induction. We observed that Metformin alone exhibited a dose-dependent anti-leukemic activity...

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Detaylı Bibliyografya
Yayımlandı:Oncotarget
Asıl Yazarlar: Voltan, Rebecca, Rimondi, Erika, Melloni, Elisabetta, Gilli, Paola, Bertolasi, Valerio, Casciano, Fabio, Rigolin, Gian Matteo, Zauli, Giorgio, Secchiero, Paola
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Impact Journals LLC 2016
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4951344/
https://ncbi.nlm.nih.gov/pubmed/26959881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7879
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