Metformin combined with sodium dichloroacetate promotes B leukemic cell death by suppressing anti-apoptotic protein Mcl-1

Metformin and the mitochondrial targeting dichloroacetate (DCA) have recently received attention due to their ability to inhibit anaerobic glycolysis, which renders most cancer cells resistant to apoptosis induction. We observed that Metformin alone exhibited a dose-dependent anti-leukemic activity...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Voltan, Rebecca, Rimondi, Erika, Melloni, Elisabetta, Gilli, Paola, Bertolasi, Valerio, Casciano, Fabio, Rigolin, Gian Matteo, Zauli, Giorgio, Secchiero, Paola
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4951344/
https://ncbi.nlm.nih.gov/pubmed/26959881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7879
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