Metformin combined with sodium dichloroacetate promotes B leukemic cell death by suppressing anti-apoptotic protein Mcl-1

Metformin and the mitochondrial targeting dichloroacetate (DCA) have recently received attention due to their ability to inhibit anaerobic glycolysis, which renders most cancer cells resistant to apoptosis induction. We observed that Metformin alone exhibited a dose-dependent anti-leukemic activity...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Voltan, Rebecca, Rimondi, Erika, Melloni, Elisabetta, Gilli, Paola, Bertolasi, Valerio, Casciano, Fabio, Rigolin, Gian Matteo, Zauli, Giorgio, Secchiero, Paola
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4951344/
https://ncbi.nlm.nih.gov/pubmed/26959881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7879
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