Ibrutinib synergizes with MDM-2 inhibitors in promoting cytotoxicity in B chronic lymphocytic leukemia

OBJECTIVE: The aim of this study was to investigate the anti-leukemic activity of the Bruton tyrosine kinase inhibitor Ibrutinib in combination with the small molecule MDM-2 inhibitor Nutlin-3 in preclinical models. METHODS: The potential efficacy of the Ibrutinib/Nutlin-3 combination was evaluated...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Voltan, Rebecca, Rimondi, Erika, Melloni, Elisabetta, Rigolin, Gian Matteo, Casciano, Fabio, Arcidiacono, Maria Vittoria, Celeghini, Claudio, Cuneo, Antonio, Zauli, Giorgio, Secchiero, Paola
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342579/
https://ncbi.nlm.nih.gov/pubmed/27661115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12139
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