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Dynamics connect substrate recognition to catalysis in protein kinase A
Atomic resolution studies of protein kinases have traditionally been carried out in the inhibitory state, limiting our current knowledge on the mechanisms of substrate recognition and catalysis. Using NMR, x-ray crystallography, and thermodynamic measurements we analyzed the substrate recognition pr...
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| Main Authors: | , , , , , , |
|---|---|
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3487389/ https://ncbi.nlm.nih.gov/pubmed/20890288 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.452 |
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