A Dominantly Acting Murine Allele of Mcm4 Causes Chromosomal Abnormalities and Promotes Tumorigenesis

Here we report the isolation of a murine model for heritable T cell lymphoblastic leukemia/lymphoma (T-ALL) called Spontaneous dominant leukemia (Sdl). Sdl heterozygous mice develop disease with a short latency and high penetrance, while mice homozygous for the mutation die early during embryonic de...

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Xehetasun bibliografikoak
Egile Nagusiak: Bagley, Bruce N., Keane, Thomas M., Maklakova, Vilena I., Marshall, Jonathon G., Lester, Rachael A., Cancel, Michelle M., Paulsen, Alex R., Bendzick, Laura E., Been, Raha A., Kogan, Scott C., Cormier, Robert T., Kendziorski, Christina, Adams, David J., Collier, Lara S.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2012
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486839/
https://ncbi.nlm.nih.gov/pubmed/23133403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003034
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