A Dominantly Acting Murine Allele of Mcm4 Causes Chromosomal Abnormalities and Promotes Tumorigenesis

Here we report the isolation of a murine model for heritable T cell lymphoblastic leukemia/lymphoma (T-ALL) called Spontaneous dominant leukemia (Sdl). Sdl heterozygous mice develop disease with a short latency and high penetrance, while mice homozygous for the mutation die early during embryonic de...

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Detalhes bibliográficos
Main Authors: Bagley, Bruce N., Keane, Thomas M., Maklakova, Vilena I., Marshall, Jonathon G., Lester, Rachael A., Cancel, Michelle M., Paulsen, Alex R., Bendzick, Laura E., Been, Raha A., Kogan, Scott C., Cormier, Robert T., Kendziorski, Christina, Adams, David J., Collier, Lara S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486839/
https://ncbi.nlm.nih.gov/pubmed/23133403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003034
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