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The β(1)-Subunit of Na(v)1.5 Cardiac Sodium Channel Is Required for a Dominant Negative Effect through α-α Interaction
Brugada syndrome (BrS) is an inherited autosomal dominant cardiac channelopathy. Several mutations on the cardiac sodium channel Na(v)1.5 which are responsible for BrS lead to misfolded proteins that do not traffic properly to the plasma membrane. In order to mimic patient heterozygosity, a traffick...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3486797/ https://ncbi.nlm.nih.gov/pubmed/23133651 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048690 |
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