Dominant-negative effect of SCN5A N-terminal mutations through the interaction of Na(v)1.5 α-subunits

AIMS: Brugada syndrome (BrS) is an autosomal-inherited cardiac arrhythmia characterized by an ST-segment elevation in the right precordial leads of the electrocardiogram and an increased risk of syncope and sudden death. SCN5A, encoding the cardiac sodium channel Na(v)1.5, is the main gene involved...

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Main Authors: Clatot, Jérôme, Ziyadeh-Isleem, Azza, Maugenre, Svetlana, Denjoy, Isabelle, Liu, Haiyan, Dilanian, Gilles, Hatem, Stéphane N., Deschênes, Isabelle, Coulombe, Alain, Guicheney, Pascale, Neyroud, Nathalie
Format: Artigo
Language:Inglês
Published: Oxford University Press 2012
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3444234/
https://ncbi.nlm.nih.gov/pubmed/22739120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvs211
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