In vivo Dominant-Negative Effect of an SCN5A Brugada Syndrome Variant

Loss-of-function mutations in the cardiac Na(+) channel α-subunit Na(v)1.5, encoded by SCN5A, cause Brugada syndrome (BrS), a hereditary disease characterized by sudden cardiac death due to ventricular fibrillation. We previously evidenced in vitro the dominant-negative effect of the BrS Na(v)1.5-R1...

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Udgivet i:Front Physiol
Main Authors: Doisne, Nicolas, Grauso, Marta, Mougenot, Nathalie, Clergue, Michel, Souil, Charlotte, Coulombe, Alain, Guicheney, Pascale, Neyroud, Nathalie
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Physiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8195286/
https://ncbi.nlm.nih.gov/pubmed/34122134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2021.661413
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