The β(1)-Subunit of Na(v)1.5 Cardiac Sodium Channel Is Required for a Dominant Negative Effect through α-α Interaction

Brugada syndrome (BrS) is an inherited autosomal dominant cardiac channelopathy. Several mutations on the cardiac sodium channel Na(v)1.5 which are responsible for BrS lead to misfolded proteins that do not traffic properly to the plasma membrane. In order to mimic patient heterozygosity, a traffick...

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Detalhes bibliográficos
Main Authors: Mercier, Aurélie, Clément, Romain, Harnois, Thomas, Bourmeyster, Nicolas, Faivre, Jean-François, Findlay, Ian, Chahine, Mohamed, Bois, Patrick, Chatelier, Aurélien
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486797/
https://ncbi.nlm.nih.gov/pubmed/23133651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048690
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