Population Pharmacokinetics of Piperacillin at Two Dose Levels: Influence of Nonlinear Pharmacokinetics on the Pharmacodynamic Profile

Piperacillin in combination with tazobactam is one of the most commonly used intravenous antibiotics. There is evidence for a possible saturable elimination of piperacillin. Therefore, the saturable elimination and its impact on the choice of optimal dosage regimens were quantified. In a randomized...

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Detalhes bibliográficos
Main Authors: Landersdorfer, Cornelia B., Bulitta, Jurgen B., Kirkpatrick, Carl M. J., Kinzig, Martina, Holzgrabe, Ulrike, Drusano, George L., Stephan, Ulrich, Sörgel, Fritz
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486597/
https://ncbi.nlm.nih.gov/pubmed/22908169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00937-12
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