Systematic Comparison of the Population Pharmacokinetics and Pharmacodynamics of Piperacillin in Cystic Fibrosis Patients and Healthy Volunteers

Respiratory tract infections cause 90% of premature mortality in patients with cystic fibrosis (CF). Treatment of Pseudomonas aeruginosa infection is often very problematic. Piperacillin-tazobactam has good activity against P. aeruginosa, but its pharmacokinetics (PK) in CF patients has not been com...

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Main Authors: Bulitta, J. B., Duffull, S. B., Kinzig-Schippers, M., Holzgrabe, U., Stephan, U., Drusano, G. L., Sörgel, F.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2007
Assuntos:
Clinical Therapeutics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1913222/
https://ncbi.nlm.nih.gov/pubmed/17485505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01477-06
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