A dose-finding, pharmacokinetic and pharmacodynamic study of a novel schedule of flavopiridol in patients with advanced solid tumors

PURPOSE: Based on the promising activity and tolerability of flavopiridol administered with a pharmacokinetically-derived dosing schedule in chronic lymphocytic leukemia (CLL), we conducted a phase I study using this schedule in patients with advanced solid tumors. EXPERIMENTAL DESIGN: Flavopiridol...

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Detalhes bibliográficos
Main Authors: Ramaswamy, Bhuvaneswari, Phelps, Mitch A., Baiocchi, Robert, Bekaii-Saab, Tanios, Ni, Wenjun, Lai, Ju-Ping, Wolfson, Anna, Lustberg, Mark E, Wei, Lai, Wilkins, Deidre, Campbell, Angela, Arbogast, Daria, Doyle, Austin, Byrd, John C, Grever, Michael R, Shah, Manisha H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486515/
https://ncbi.nlm.nih.gov/pubmed/20938713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-010-9563-7
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