A Pharmacokinetic/Pharmacodynamic Model of Tumor Lysis Syndrome in Chronic Lymphocytic Leukemia Patients Treated with Flavopiridol

PURPOSE: Flavopiridol, the first clinically evaluated cyclin dependent kinase inhibitor, demonstrates activity in patients with refractory chronic lymphocytic leukemia, but prevalent and unpredictable tumor lysis syndrome (TLS) presents a major barrier to its broad clinical use. The purpose of this...

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Detalhes bibliográficos
Main Authors: Ji, Jia, Mould, Diane R., Blum, Kristie A., Ruppert, Amy S., Poi, Ming, Zhao, Yuan, Johnson, Amy J., Byrd, John C., Grever, Michael R., Phelps, Mitch A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3845832/
https://ncbi.nlm.nih.gov/pubmed/23300276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-1092
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