Secretion of Dopa in Phaeochromocytoma

door Louis, William J., Doyle, Austin E., Heath, William C., Robinson, Maxwell J.
Gepubliceerd in 1972

LC-MS/MS assay for the quantitation of the ATR kinase inhibitor VX-970 in human plasma

door Kiesel, Brian F., Scemama, Jonas, Parise, Robert A., Villaruz, Liza, Iffland, Andre, Doyle, Austin, Ivy, Percy, Chu, Edward, Bakkenist, Christopher J., Beumer, Jan H.
Gepubliceerd in J Pharm Biomed Anal (2017)

Results of an abbreviated phase-II study with the Akt Inhibitor MK-2206 in Patients with Advanced Biliary Cancer

door Ahn, Daniel H., Li, Junan, Wei, Lai, Doyle, Austin, Marshall, John L., Schaaf, Larry J., Phelps, Mitch A., Villalona-Calero, Miguel A., Bekaii-Saab, Tanios
Gepubliceerd in Sci Rep (2015)

University of Chicago Phase II Consortium Trial of Selumetinib (MEKi) Demonstrates Low Tolerability and Efficacy in Relapsed DLBCL

door Galanina, Natalie, Smith, Sonali M., Liao, Chuanhong, Petrich, Adam, Libao, Bernadette, Gartenhaus, Ronald, Westin, Jason, Cohen, Kenneth S, Knost, James A., Stadler, Walter M., Doyle, Austin, Karrison, Theodore, Gordon, Leo, Evens, Andrew M.
Gepubliceerd in Br J Haematol (2017)

A phase I study of selumetinib (AZD6244/ARRY-142866), a MEK1/2 inhibitor, in combination with cetuximab in refractory solid tumors and KRAS mutant colorectal cancer

door Deming, Dustin A., Cavalcante, Ludmila L., Lubner, Sam J., Mulkerin, Daniel L., LoConte, Noelle K., Eickhoff, Jens C., Kolesar, Jill M., Fioravanti, Suzanne, Greten, Tim F., Compton, Kathryn, Doyle, Austin G., Wilding, George, Duffy, Austin, Liu, Glenn
Gepubliceerd in Invest New Drugs (2015)

A dose-finding, pharmacokinetic and pharmacodynamic study of a novel schedule of flavopiridol in patients with advanced solid tumors

door Ramaswamy, Bhuvaneswari, Phelps, Mitch A., Baiocchi, Robert, Bekaii-Saab, Tanios, Ni, Wenjun, Lai, Ju-Ping, Wolfson, Anna, Lustberg, Mark E, Wei, Lai, Wilkins, Deidre, Campbell, Angela, Arbogast, Daria, Doyle, Austin, Byrd, John C, Grever, Michael R, Shah, Manisha H.
Gepubliceerd in 2010

NFM-07. SPRINT: PHASE II STUDY OF THE MEK 1/2 INHIBITOR SELUMETINIB (AZD6244, ARRY-142886) IN CHILDREN WITH NEUROFIBROMATOSIS TYPE 1 (NF1) AND INOPERABLE PLEXIFORM NEUROFIBROMAS (P...

door Gross, Andrea, Wolters, Pamela, Baldwin, Andrea, Dombi, Eva, Fisher, Michael J, Weiss, Brian, Kim, AeRang, Blakeley, Jaishri, Whitcomb, Patricia, Holmblad, Marielle, Maritin, Staci, Roderick, Marie Claire, Paul, Scott M, Therrien, Janet, Heisey, Kara, Doyle, Austin, Smith, Malcolm, Glod, John, Steinberg, Seth, Widemann, Brigitte C
Gepubliceerd in Neuro Oncol (2018)

Phase II, 2-Stage, 2-Arm, PIK3CA Mutation Stratified Trial of MK-2206 in Recurrent Endometrial Cancer

door Myers, Andrea P., Konstantinopoulos, Panagiotis A., Barry, William T., Luo, Weixiu, Broaddus, Russell R., Makker, Vicky, Drapkin, Ronny, Liu, Joyce, Doyle, Austin, Horowitz, Neil S., Meric-Bernstam, Funda, Birrer, Michael, Aghajanian, Carol, Coleman, Robert L., Mills, Gordon B., Cantley, Lewis C., Matulonis, Ursula A., Westin, Shannon N.
Gepubliceerd in Int J Cancer (2019)

Phase I Trial of Bortezomib (PS-341; NSC 681239) and Alvocidib (Flavopiridol; NSC 649890) in Patients with Recurrent or Refractory B-cell Neoplasms

door Holkova, Beata, Perkins, E. Brent, Ramakrishnan, Viswanathan, Tombes, Mary Beth, Shrader, Ellen, Talreja, Neha, Wellons, Martha D., Hogan, Kevin T., Roodman, G. David, Coppola, Domenico, Kang, Loveleen, Dawson, Jana, Stuart, Robert K., Peer, Cody, Figg, William D., Kolla, Sarah, Doyle, Austin, Wright, John, Sullivan, Daniel M., Roberts, John D., Grant, Steven
Gepubliceerd in 2011

Molecular Profiling and Targeted Therapy for Advanced Thoracic Malignancies: A Biomarker-Derived, Multiarm, Multihistology Phase II Basket Trial

door Lopez-Chavez, Ariel, Thomas, Anish, Rajan, Arun, Raffeld, Mark, Morrow, Betsy, Kelly, Ronan, Carter, Corey Allan, Guha, Udayan, Killian, Keith, Lau, Christopher C., Abdullaev, Zied, Xi, Liqiang, Pack, Svetlana, Meltzer, Paul S., Corless, Christopher L., Sandler, Alan, Beadling, Carol, Warrick, Andrea, Liewehr, David J., Steinberg, Seth M., Berman, Arlene, Doyle, Austin, Szabo, Eva, Wang, Yisong, Giaccone, Giuseppe
Gepubliceerd in J Clin Oncol (2015)

Activity of Selumetinib in Neurofibromatosis Type 1–Related Plexiform Neurofibromas

door Dombi, Eva, Baldwin, Andrea, Marcus, Leigh J., Fisher, Michael J., Weiss, Brian, Kim, AeRang, Whitcomb, Patricia, Martin, Staci, Aschbacher-Smith, Lindsey E., Rizvi, Tilat A., Wu, Jianqiang, Ershler, Rachel, Wolters, Pamela, Therrien, Janet, Glod, John, Belasco, Jean B., Schorry, Elizabeth, Brofferio, Alessandra, Starosta, Amy J., Gillespie, Andrea, Doyle, Austin L., Ratner, Nancy, Widemann, Brigitte C.
Gepubliceerd in N Engl J Med (2016)

A Phase 2 Trial of AZD6244 (Selumetinib, ARRY-142886), an Oral MEK1/2 Inhibitor, in Relapsed/Refractory Multiple Myeloma

door Holkova, Beata, Zingone, Adriana, Kmieciak, Maciej, Bose, Prithviraj, Badros, Ashraf Z., Voorhees, Peter M., Baz, Rachid, Korde, Neha, Lin, Hui-Yi, Chen, Jin-Qiu, Herrmann, Michelle, Xi, Liqiang, Raffeld, Mark, Zhao, Xiuhua, Wan, Wen, Tombes, Mary Beth, Shrader, Ellen, Weir-Wiggins, Caryn, Sankala, Heidi, Hogan, Kevin T., Doyle, Austin, Annunziata, Christina M., Wellons, Martha, Roberts, John D., Sullivan, Daniel, Landgren, Ola, Grant, Steven
Gepubliceerd in Clin Cancer Res (2015)

Relationship between Physician-Adjudicated Adverse Events and Patient-Reported Health-Related Quality of Life in a Phase II Clinical Trial (NCT01143402) of Patients with Metastatic...

door Atkinson, Thomas M., Hay, Jennifer L., Shoushtari, Alexander, Li, Yuelin, Paucar, Daniel J., Smith, Sloane C., Kudchadkar, Ragini R., Doyle, Austin, Sosman, Jeffrey A., Quevedo, Jorge Fernando, Milhem, Mohammed M., Joshua, Anthony M., Linette, Gerald P., Gajewski, Thomas F., Lutzky, Jose, Lawson, David H., Lao, Christopher D., Flynn, Patrick J., Albertini, Mark R., Sato, Takami, Lewis, Karl, Marr, Brian, Abramson, David H., Dickson, Mark Andrew, Schwartz, Gary K., Carvajal, Richard D.
Gepubliceerd in J Cancer Res Clin Oncol (2016)

Effect of Selumetinib versus Chemotherapy on Progression-Free Survival in Uveal Melanoma: A Randomized Clinical Trial

door Carvajal, Richard D., Sosman, Jeffrey A., Quevedo, Jorge Fernando, Milhem, Mohammed M., Joshua, Anthony Michael, Kudchadkar, Ragini R., Linette, Gerald P., Gajewski, Thomas F., Lutzky, Jose, Lawson, David H., Lao, Christopher D., Flynn, Patrick J., Albertini, Mark R., Sato, Takami, Lewis, Karl, Doyle, Austin, Ancell, Kristin, Panageas, Katherine S., Bluth, Mark, Hedvat, Cyrus, Erinjeri, Joseph, Ambrosini, Grazia, Marr, Brian, Abramson, David, Dickson, Mark Andrew, Wolchok, Jedd D., Chapman, Paul B., Schwartz, Gary K.
Gepubliceerd in JAMA (2014)

LGG-02. A PHASE II PROSPECTIVE TRIAL OF SELUMETINIB IN CHILDREN WITH RECURRENT/PROGRESSIVE PEDIATRIC LOW-GRADE GLIOMA (PLGG) WITH A FOCUS UPON OPTIC PATHWAY/HYPOTHALAMIC TUMORS AND...

door Fangusaro, Jason, Onar-Thomas, Arzu, Poussaint, Tina Young, Wu, Shengjie, Ligon, Azra H, Lindeman, Neal, Banerjee, Anu, Packer, Roger J, Kilburn, Lindsay B, Goldman, Stewart, Pollack, Ian F, Jakacki, Regina I, Qaddoumi, Ibrahim, Fisher, Paul G, Dhall, Girish, Baxter, Patricia, Kreissman, Susa G, Stewart, Clinton F, Jones, David T W, Pfister, Stefan M, Vezina, Gilbert, Stern, Jessica S, Panigrahy, Ashok, Jones, Blaise V, Patay, Zoltan, Tamrazi, Benita, Jones, Jeremy Y, Haque, Sofia S, Enterline, David S, Cha, Soonme, Fisher, Michael J, Doyle, Austin, Smith, Malcolm, Fouladi, Maryam, Dunkel, Ira J
Gepubliceerd in Neuro Oncol (2019)