Molecular Profiling and Targeted Therapy for Advanced Thoracic Malignancies: A Biomarker-Derived, Multiarm, Multihistology Phase II Basket Trial

PURPOSE: We conducted a basket clinical trial to assess the feasibility of such a design strategy and to independently evaluate the effects of multiple targeted agents against specific molecular aberrations in multiple histologic subtypes concurrently. PATIENTS AND METHODS: We enrolled patients with...

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Detalhes bibliográficos
Publicado no:J Clin Oncol
Main Authors: Lopez-Chavez, Ariel, Thomas, Anish, Rajan, Arun, Raffeld, Mark, Morrow, Betsy, Kelly, Ronan, Carter, Corey Allan, Guha, Udayan, Killian, Keith, Lau, Christopher C., Abdullaev, Zied, Xi, Liqiang, Pack, Svetlana, Meltzer, Paul S., Corless, Christopher L., Sandler, Alan, Beadling, Carol, Warrick, Andrea, Liewehr, David J., Steinberg, Seth M., Berman, Arlene, Doyle, Austin, Szabo, Eva, Wang, Yisong, Giaccone, Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2015
Assuntos:
ORIGINAL REPORTS
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356709/
https://ncbi.nlm.nih.gov/pubmed/25667274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2014.58.2007
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