A dose-finding and pharmacodynamic study of bortezomib in combination with weekly paclitaxel in patients with advanced solid tumors

PURPOSE: A phase I study to determine the maximum tolerated dose (MTD) of bortezomib (B) when combined with weekly paclitaxel in patients with advanced solid tumors. PATIENTS AND METHODS: Eligible patients received escalating doses of intravenous (IV) bortezomib (0.6–2 mg/m(2)) on days 2 and 9 and I...

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Detalhes bibliográficos
Main Authors: Ramaswamy, Bhuvaneswari, Bekaii-Saab, Tanios, Schaaf, Larry J., Lesinski, Gregory B., Lucas, David M., Young, Donn C., Ruppert, Amy S., Byrd, John C., Culler, Kristy, Wilkins, Diedre, Wright, John J., Grever, Michael R., Shapiro, Charles L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3540804/
https://ncbi.nlm.nih.gov/pubmed/19774377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-009-1145-z
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