A dose-finding and pharmacodynamic study of bortezomib in combination with weekly paclitaxel in patients with advanced solid tumors

PURPOSE: A phase I study to determine the maximum tolerated dose (MTD) of bortezomib (B) when combined with weekly paclitaxel in patients with advanced solid tumors. PATIENTS AND METHODS: Eligible patients received escalating doses of intravenous (IV) bortezomib (0.6–2 mg/m(2)) on days 2 and 9 and I...

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Bibliografiska uppgifter
Huvudupphovsmän: Ramaswamy, Bhuvaneswari, Bekaii-Saab, Tanios, Schaaf, Larry J., Lesinski, Gregory B., Lucas, David M., Young, Donn C., Ruppert, Amy S., Byrd, John C., Culler, Kristy, Wilkins, Diedre, Wright, John J., Grever, Michael R., Shapiro, Charles L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3540804/
https://ncbi.nlm.nih.gov/pubmed/19774377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-009-1145-z
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