HIV Control through a Single Nucleotide on the HLA-B Locus

Genetic variation within the HLA-B locus has the strongest impact on HIV disease progression of any polymorphisms within the human genome. However, identifying the exact mechanism involved is complicated by several factors. HLA-Bw4 alleles provide ligands for NK cells and for CD8 T cells, and strong...

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Bibliographische Detailangaben
Hauptverfasser: Kløverpris, Henrik N., Harndahl, Mikkel, Leslie, Alasdair J., Carlson, Jonathan M., Ismail, Nasreen, van der Stok, Mary, Huang, Kuan-Hsiang Gary, Chen, Fabian, Riddell, Lynn, Steyn, Dewald, Goedhals, Dominique, van Vuuren, Cloete, Frater, John, Walker, Bruce D., Carrington, Mary, Ndung'u, Thumbi, Buus, Søren, Goulder, Philip
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2012
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486337/
https://ncbi.nlm.nih.gov/pubmed/22896606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01020-12
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