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CYLD inhibits melanoma growth and progression through suppression of the JNK/AP-1 and β1-integrin signaling pathways
The molecular mechanisms mediating CYLD tumor suppressor function appear to be manifold. Here, we demonstrated that, in contrast to the increased levels of pJNK, CYLD was decreased in a majority of melanoma cell lines and tissues examined. Exogenous expression of CYLD but not its catalytically defic...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3485435/ https://ncbi.nlm.nih.gov/pubmed/22832488 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2012.253 |
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